Facilities
The Proteomics
Center is the newest core research facility under the umbrella
of the
Molecular
Biology Program. It is being developed through the collaborative
efforts of the Office of Research, the Molecular Biology Program,
the College
of Arts and Sciences, and the College of Agriculture, Food and Natural
Resources. The Proteomics Center offers state-of-the-art technologies
in protein and peptide analysis to all MU researchers. For more information,
contact Center director John Walker at WalkerJ@missouri.edu.
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The DNA Core provides DNA sequencing, genotyping, SNP detection and
analysis and microarray services; maintains a freezer inventory program
for molecular biology enzymes and reagents; and provides support for
computer analysis of nucleic acid and protein sequence data. Robotic
instrumentation is available for high throughput plasmid isolation,
colony picking and genomic library management. The Affymetrix GeneChip®
System has also been added to the DNA Core. The GeneChip® Instrument
System is a fully integrated platform for Affymetrix application-specific
oligonucleotide arrays, the GeneChip® probe arrays. The integrated
system includes the GeneArrayT scanner, the GeneChip® Fluidics
Station (model 400), the GeneChip® Hybridization Oven 640, and
a powerful computer workstation loaded with the Affymetrix Microarray
Suite. The
Core is hosted by the Dept. of Molecular Microbiology and Immunology.
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The MCC is a resource for all types of light microscopy, immunocytochemistry,
in situ hybridization techniques and general scientific image analysis
and processing. Instrumentation available for client use includes two
confocal microscopes, micro-injection system, epi-fluorescence stereoscope,
conventional wide-field microscopes, paraffin microtome, cryostat,
and ultramicrotome. The MCC is hosted by the Life Sciences Center.
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Sears Plant Growth Facility
 The
Ernie and Lotti M.S. Sears Plant Growth Facility contains 12 greenhouses,
walk-in growth chambers, a state of the art tissue culture and transformation
laboratory and long-term seed storage rooms for the preservation
of
genetic resources.
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The plant transformation
core facilty is located in the Sears Plant Growth Facility and
provides
services for the production of transgenic maize, soybean, Arabidopsis,
and tobacco. The PTC is hosted by the College of Agriculture,
Food
and Natural Resources.
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The CIC provides custom
monoclonal antibodies, flow cytometric analysis and tissue culture
reagents. The Core is hosted by the Dept. of Molecular Microbiology
and Immunology.
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The EMC is a campus-wide resource center for research that requires
scanning or transmission electron microscopy, providing investigators
in both life sciences and material sciences with consultation, training
and services. The facility was established with resources from the
College
of Veterinary Medicine, the School of Medicine, the College of Agriculture,
Food and Natural Resources, the Department of Geological Sciences
and
the Molecular Biology Program. The Core is hosted by the Department
of Veterinary Pathobiology.
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The NMR Core, located in the Department of Chemistry, now operates
under the administrative umbrella of the Molecular Biology Program.
Instrumentation
includes a Varian Inova 600 MHz spectrometer, a Bruker DRX 500 MHz
spectrometer, an ARX 250MHz spectrometer and a DRX 300 MHz (widebore)
spectrometer
with solid state capability. All these spectrometers have multinuclear
capability. The NMR Facility and staff are available for research
support
to investigators who want to use NMR for structural elucidation and
study of chemical and biological reactions. Assistance in the design
of experiments and spectral analysis is available upon request. Directed
by Professor of Chemistry Tuck Wong.
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The Structural Biology Core Facility (SBC) offers assistance in unraveling
the three-dimensional structure of biological molecules by providing
technical expertise in protein purification and crystallization and
instrumentation for NMR Spectroscopy and X-ray diffraction analysis.
Beamline services are also available through the SBC. The SBC has been
established under the umbrella of the Molecular Biology Program. Supported
by Mission Enhancement, the Depts. of Biochemistry and Chemistry, and
the Molecular Biology Program.
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